ABSTRACT
The construction and electrochemical response characteristics of polymeric membrane sensor was investigated for potentiometric determination of meloxicam. The construction of the sensor was based on the incorporation of meloxicam-phosphomolybdate ion-pair in a poly [vinyl chloride] matrix. Linear response over the concentration range of 10[-5]-10[-2] M with anionic slope 55.42 mV per concentration decade. The direct potentiometric determination of meloxicam in pure forms using meloxicam-phosphomolybdate sensor gave average recovery of 99.83 +/- 0.7. The results obtained by the proposed procedure were statistically analyzed and compared with those obtained by using the reported method. The proposed sensor was also applied successfully to the determination of the drug in pharmaceutical preparations and biological fluids. The presence of tablet's excipients did not interfere with the determination of the drug or with the accuracy precision of the proposed method
Subject(s)
Potentiometry , Pharmaceutical Preparations , Electrodes , Thiazoles/analysisABSTRACT
The sensitivity and selectivity of a propranolol-selective membrane electrode have been improved with the use of propranolol-ammonium reineckate as electroactive material in the presence of di-butyl sebacate as plasticizer and tetrahydrofuran as solvent mediator. The electrode exhibited a near-Nernstain response over a concentration range of 1x10-2 -5x10-6M propranolol hydrochloride with a slope of 52.7+/-0.6 mV per decade. The practical pH range was 3-8. Interferences from common cations, alkaloids and drug excipients were reported. The proposed electrode has been successfully applied to determine propranolol hydrochloride in pure form and pharmaceutical preparations. The results were correlated well with those obtained by BP standard procedure